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Paolo Falcaro (Technische Universität Graz)


Biomimetic Mineralization of MOFs

Graz University of Technology, Institute of Physical and Theoretical Chemistry, Austria
The University of Adelaide, Department of Chemistry, Australia

Keywords: self-assembly, mineralization, biomolecule, MOF composite, bio-MOF

Among the different classes of Metal-organic Framework (MOF) composites prepared during recent years using ceramic, metallic and polymeric nanoparticles,[1-4] a newe merging type of MOF composite has been recently obtained encapsulating bio-macromolecules within MOFs.[5-7] In physiological solutions,co-precipitation and biomimetic mineralization methods have been used to self-assemble MOFs around bio-active compounds (e.g., enzymes). The biomimetic mineralization of MOF bio-composites enables the fast encapsulation of guests larger than micropores of MOFs.[8] This new class of bio-composites have shown unprecedented properties for biotechnological applications.[9] In this presentation, we will discuss about different biomacromolecules (e.g., proteins, carbohydrates) and complex biological systems (yeast cells) as crystallization agents for MOFs.[10–13] The functional properties of these composites will be disclosed providing examples of other methods used for the encapsulation of proteins within MOFs, including the preparation of hollow MOF capsules.[14,15] Exciting potential applications of these new MOF bio-composites and current challenges will be presented.[8,16]

[1] P. Falcaro, R. Ricco, A. Yazdi, I. Imaz, S. Furukawa, D. Maspoch, R. Ameloot, J. D. Evans and C. J. Doonan, Coord. Chem. Rev. 307, 237–254, 2016
[2] Q.-L. Zhu and Q. Xu, Chem. Soc. Rev. 43, 5468–5512, 2014
[3] C. M. Doherty, D. Buso, A. J. Hill, S. Furukawa, S. Kitagawa and P. Falcaro, Acc. Chem. Res., 47, 396–405, 2014
[4] G. Li, H. Kobayashi, J. M. Taylor, R. Ikeda, Y. Kubota, K. Kato, M. Takata, T. Yamamoto, S. Toh, S. Matsumura and H. Kitagawa, Nat. Mater., 13, 802–806, 2014
[5] F. Lyu, Y. Zhang, R. N. Zare, J. Ge and Z. Liu, Nano Lett., 14, 5761–5765, 2014
[6] K. Liang, R. Ricco, C. M. Doherty, M. J. Styles, S. Bell, N. Kirby, S. Mudie, D. Haylock, A. J. Hill, C. J. Doonan and P. Falcaro, Nat. Commun., 6, 7240, 2015
[7] F.-K. Shieh, S.-C. Wang, C.-I. Yen, C.-C. Wu, S. Dutta, L.-Y. Chou, J. V. Morabito, P. Hu, M.-H. Hsu, K. C.-W. Wu and C.-K. Tsung, J. Am. Chem. Soc., 137, 4276–4279, 2015
[8] R. Riccò, W. Liang, S. Li, J. J. Gassensmith, F. Caruso, C. Doonan and P. Falcaro, ACS Nano, 12, 13–23, 2018
[9] C. Doonan, R. Riccò, K. Liang, D. Bradshaw and P. Falcaro, Acc. Chem. Res., 50, 1423–1432, 2017
[10] N. K. Maddigan, A. Tarzia, D. M. Huang, C. J. Sumby, S. G. Bell, P. Falcaro and C. J. Doonan, Chem. Sci., 9, 4217–4223, 2018
[11] W. Liang, H. Xu, F. Carraro, N. K. Maddigan, Q. Li, S. G. Bell, D. M. Huang, A. Tarzia, M. B. Solomon, H. Amenitsch, L. Vaccari, C. J. Sumby, P. Falcaro and C. J. Doonan, J. Am. Chem. Soc., 141, 2348–2355, 2019
[12] E. Astria, M. Thonhofer, R. Ricco, W. Liang, A. Chemelli, A. Tarzia, K. Alt, C. E. Hagemeyer, J. Rattenberger, H. Schroettner, T. Wrodnigg, H. Amenitsch, D. M. Huang, C. J. Doonan and P. Falcaro, Mater. Horiz., 2019. DOI: 10.1039/C8MH01611A
[13] K. Liang, J. J. Richardson, J. Cui, F. Caruso, C. J. Doonan and P. Falcaro, Adv. Mater., 28, 7910–7914, 2016
[14] J. Huo, J. Aguilera-Sigalat, S. El-Hankari and D. Bradshaw, Chem. Sci., 6, 1938–1943, 2015
[15] G.-Y. Jeong, R. Ricco, K. Liang, J. Ludwig, J.-O. Kim, P. Falcaro and D.-P. Kim, Chem. Mater., 27, 7903–7909, 2015
[16] K. Liang, C. Carbonell, M. J. Styles, R. Ricco, J. Cui, J. J. Richardson, D. Maspoch, F. Caruso and P. Falcaro, Adv. Mater., 27, 7293–7298, 2015